Open Access<p>Expression of Hypoxia-Inducible Factor-1α (HIF1A) and Lp-PLA2 in Low, Intermediate, and High Cardiovascular Disease Risk Population</p>
Author(s) -
Teuku Heriansyah,
Indah Nur Chomsy,
Kumboyono Kumboyono,
Pinandita Annisa Pratiwi,
Titin Andri Wihastuti
Publication year - 2020
Publication title -
vascular health and risk management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.892
H-Index - 68
eISSN - 1178-2048
pISSN - 1176-6344
DOI - 10.2147/vhrm.s283367
Subject(s) - medicine , hif1a , hypoxia (environmental) , risk factor , population , lipoprotein associated phospholipase a2 , inflammation , endocrinology , immunology , lipoprotein , angiogenesis , oxygen , cholesterol , chemistry , environmental health , organic chemistry
The pathomechanism of CVD is a complex and multifactorial process. The primary mechanism of CVD is atherosclerosis. Inflammation in atherogenesis raises the risk of hypoxia, which will activate hypoxia-inducible factor-1α (HIF1A). Also, together with lipoprotein-associated phospholipase A2 (Lp-PLA2), an inflammatory mediator for atherogenesis.