Open Access<p>Effect of Long-Term Allopurinol Therapy on Left Ventricular Mass Index in Patients with Ischemic Heart Disease; A Cross-Sectional Study</p>
Author(s) -
Manal M. Alem,
Sarah Aldosari,
Alhassna A Alkahmous,
Adam S Obad,
Nagy M Fagir,
Bandar AlGhamdi
Publication year - 2019
Publication title -
vascular health and risk management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.892
H-Index - 68
eISSN - 1178-2048
pISSN - 1176-6344
DOI - 10.2147/vhrm.s226009
Subject(s) - medicine , allopurinol , cardiology , left ventricular hypertrophy , creatinine , renal function , ejection fraction , blood pressure , uric acid , body mass index , risk factor , heart failure
Left ventricular hypertrophy (LVH), as assessed by measurement of left ventricular mass (LVM), is one of the most important cardiovascular risk factors. It is commonly present in patients with ischemic heart disease (IHD), irrespective of the level of blood pressure; recently, oxidative stress has been shown to be an important factor in its development. The question then arises: can this risk factor be modified by antioxidant treatment (e.g., with allopurinol, a xanthine oxidase inhibitor)?