Open AccessEfficacy and Safety of Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria in Pregnant Women: A Systematic Review and Meta-Analysis
Author(s) -
Workineh Shibeshi,
Assefa Mulu Baye,
Getachew Alemkere,
Ephrem Engidawork
Publication year - 2021
Publication title -
therapeutics and clinical risk management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 55
eISSN - 1178-203X
pISSN - 1176-6336
DOI - 10.2147/tcrm.s336771
Subject(s) - medicine , artemisinin , malaria , meta analysis , pregnancy , combination therapy , cochrane library , systematic review , pharmacovigilance , medline , adverse effect , intensive care medicine , plasmodium falciparum , immunology , biology , political science , law , genetics
Malaria is one of the infectious diseases with substantial risks for pregnant women, the fetus and the newborn child. Thus, prevention and treatment of malaria with safe and effective drugs is of paramount importance. Pregnant women are mostly excluded from clinical trials, and systematic approaches of pharmacovigilance in pregnancy are limited. This means the safety and efficacy of antimalarial agents during pregnancy are unclear.