Open Access<p>The Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Growth Factor and Serum Levels of Interleukin 6 and 8 in Women with Breast Cancer: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>
Author(s) -
Nazanin Zahrooni,
Seyed Ahmad Hosseini,
Ahmad Ahmadzadeh,
Kambiz Ahmadi Angali,
Mohammad-Ali Assarehzadegan
Publication year - 2019
Publication title -
therapeutics and clinical risk management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 55
eISSN - 1178-203X
pISSN - 1176-6336
DOI - 10.2147/tcrm.s234930
Subject(s) - medicine , coenzyme q10 , placebo , breast cancer , vascular endothelial growth factor , tamoxifen , gastroenterology , randomized controlled trial , cancer , cytokine , inflammation , placebo controlled study , double blind , vegf receptors , pathology , alternative medicine
To better evaluate the efficacy of CoQ10 on the inflammatory markers in breast cancer patients, we conducted a clinical study of patients with breast cancer undergoing tamoxifen therapy. CoQ10 serves as an antioxidant and inhibits oxidation caused by reactive oxygen species. The aim of the current study was to assess the effect of coenzyme Q10 supplementation on serum levels of interleukin 6, 8, and vascular endothelial growth factor (VEGF) in patients with breast cancer undergoing tamoxifen therapy by a double-blind, placebo-controlled, randomized clinical trial.