Open Access<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>
Author(s) -
Anastasios Kyriazoglou,
Konstantinos Koutsoukos,
Flora Zagouri,
Michalis Liontos,
Efthimios Dimitriadis,
Dina Tiniakos,
Meletios A. Dimopoulos
Publication year - 2020
Publication title -
therapeutics and clinical risk management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.719
H-Index - 55
eISSN - 1178-203X
pISSN - 1176-6336
DOI - 10.2147/tcrm.s220804
Subject(s) - medicine , epithelioid hemangioendothelioma , star (game theory) , oncology , gastroenterology , cancer research , immunohistochemistry , mathematical analysis , mathematics
Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.