Open AccessITPA:c.94C>A and NUDT15:c.415C>T Polymorphisms and Their Relation to Mercaptopurine-Related Myelotoxicity in Childhood Leukemia in Thailand
Author(s) -
Boonchai Boonyawat,
Chalinee Monsereenusorn,
Apichat Photia,
Nawachai Lertvivatpong,
Varissara Kaewchaivijit,
Punyanuch Jindatanmanusan,
Piya Rujkijyat
Publication year - 2021
Publication title -
application of clinical genetics
Language(s) - English
Resource type - Journals
ISSN - 1178-704X
DOI - 10.2147/tacg.s318912
Subject(s) - itpa , mercaptopurine , medicine , thiopurine methyltransferase , gastroenterology , leukemia , immunology , azathioprine , disease , ribavirin , hepatitis c virus , virus
Mercaptopurine is a key agent in childhood leukemia treatment. Genetic polymorphism in the genes involving thiopurine metabolisms is related to 6-MP related toxicity.