Open Access<p>The Human Genetic Variants CYP2J2 rs2280275 and EPHX2 rs751141 and Risk of Diabetic Nephropathy in Egyptian Type 2 Diabetic Patients</p>
Author(s) -
Mona Salah Eldin Habieb,
Ashraf Dawood,
Mahmoud Emara,
Mohammad G. Elhelbawy,
Nesreen G Elhelbawy
Publication year - 2020
Publication title -
application of clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.879
H-Index - 32
ISSN - 1178-704X
DOI - 10.2147/tacg.s281502
Subject(s) - medicine , diabetic nephropathy , creatinine , genetic predisposition , diabetes mellitus , single nucleotide polymorphism , gastroenterology , type 2 diabetes mellitus , genotyping , kidney disease , type 2 diabetes , endocrinology , renal function , genotype , disease , genetics , biology , gene
Diabetic nephropathy (DN), the primary driver of end-stage kidney disease, is a problem with serious consequences for society's health. Single nucleotide polymorphisms (SNPs) can define differences in susceptibility to DN and aid in development of personalized treatment. Giving the importance of epoxyeicosatrienoic acids (EETs) in kidney health, we aimed to study the association between two SNPs in the genes controlling synthesis and degradation of EETs (CYP2J2 rs2280275 and EPHX2 rs751141 respectively) and susceptibility of type 2 diabetes mellitus (T2DM) patients to develop DN.