Open AccessGenetic Predictors of Mortality in Patients with Multiple Myeloma
Author(s) -
Hamza Hassan,
Raphaël Szalat
Publication year - 2021
Publication title -
application of clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.879
H-Index - 32
ISSN - 1178-704X
DOI - 10.2147/tacg.s262866
Subject(s) - multiple myeloma , epigenomics , copy number variation , biology , genomics , disease , genome instability , comparative genomic hybridization , somatic evolution in cancer , chromothripsis , genetics , transcriptome , computational biology , bioinformatics , dna methylation , gene , medicine , genome , immunology , dna , gene expression , dna damage
Multiple myeloma (MM) is a heterogeneous disease featured by clonal plasma cell proliferation and genomic instability. The advent of next-generation sequencing allowed unraveling the complex genomic landscape of the disease. Several recurrent genomic aberrations including immunoglobulin genes translocations, copy number abnormalities, complex chromosomal events, transcriptomic and epigenomic deregulation, and mutations define various molecular subgroups with distinct outcomes. In this review, we describe the recurrent genomic events identified in MM impacting patients' outcome and survival. These genomic aberrations constitute new markers that could be incorporated into a prognostication model to eventually guide therapy at every stage of the disease.