Open Access<p>The Impact of the Genetic Polymorphism in DNA Repair Pathways on Increased Risk of Glioblastoma Multiforme in the Arab Jordanian Population: A Case–Control Study</p>
Author(s) -
Sohaib M Al-Khatib,
Nour Abdo,
Laith N. AL-Eitan,
Abdel-Hameed Al-Mistarehi,
Deeb Jamil Zahran,
Marwan Al Ajlouni,
Tariq Kewan
Publication year - 2020
Publication title -
application of clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.879
H-Index - 32
ISSN - 1178-704X
DOI - 10.2147/tacg.s248994
Subject(s) - xrcc1 , glioblastoma , oncology , medicine , snp , population , ercc2 , genetics , genotype , single nucleotide polymorphism , gene , biology , cancer research , environmental health
Among the Jordanian population, brain tumors are the tenth most common type of cancers in both males and females, comprising 2.8% of all newly diagnosed neoplasms. Diffuse gliomas are the most prevalent and the most aggressive primary brain tumors in adults. The incidence of diffuse gliomas varies among different populations; this variation is partially linked to genetic polymorphisms. The purpose of the study is to examine the association between (BRCA1 rs799917G>A, rs1799966T>C, EXO1 rs1047840G>A, EME1 rs12450550T>C, ERCC2 rs13181T>G, rs1799793C>T, and XRCC1 rs1799782G>A) DNA repair gene polymorphisms and glioblastoma multiforme (GBM) susceptibility, and survival in the Jordanian Arab population.