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Warfarin continues to be the most widely used anticoagulant in clinical practice around the world for the prevention of thromboembolic events in patients with atrial fibrillation (AF). The evaluation of the quality of anticoagulation control, estimated by time in therapeutic range (TTR), is accepted as a good method to evaluate the quality of anticoagulation. The variability of TTR can be explained by the presence of variants of the CYP2C9 and VKORC1 genes.

the application of clinical genetics

&lt;p&gt;Polymorphisms of &lt;em&gt;CYP2C9*2&lt;/em&gt;, &lt;em&gt;CYP2C9*3&lt;/em&gt; and &lt;em&gt;VKORC1&lt;/em&gt; genes related to time in therapeutic range in patients with atrial fibrillation using warfarin&lt;/p&gt;