Open AccessHypoxia Effects in Intervertebral Disc-Derived Stem Cells and Discus Secretomes: An in vitro Study
Author(s) -
- Romaniyanto,
Ferdiansyah Mahyudin,
Cita Rosita Sigit Prakoeswa,
Hari Basuki Notobroto,
Damayanti Tinduh,
Ryan Ausrin,
Fedik Abdul Rantam,
Heri Suroto,
Dwikora Novembri Utomo,
Сholahuddin Рhatomy
Publication year - 2022
Publication title -
stem cells and cloning
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 22
ISSN - 1178-6957
DOI - 10.2147/sccaa.s363951
Subject(s) - hypoxia (environmental) , platelet derived growth factor receptor , vascular endothelial growth factor , fibroblast growth factor , in vitro , growth factor , chemistry , transforming growth factor , microbiology and biotechnology , biology , medicine , endocrinology , vegf receptors , biochemistry , oxygen , receptor , organic chemistry
This study aimed to investigate the effects of hypoxia and normoxia preconditioning in rabbit intervertebral disc-derived stem cells (IVDSCs) and discus-derived conditioned medium (DD-CM)/secretomes in vitro. Transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF) have a role in the proliferation, development, differentiation, and migration of MSCs.