Open Access<p>Effects of Growth Factors and the MicroRNA-183 Family on Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Towards Auditory Neuron-Like Cells</p>
Author(s) -
Gholamreza Farnoosh,
Mohammad-Reza Mahmoudian-Sani
Publication year - 2020
Publication title -
stem cells and cloning
Language(s) - English
Resource type - Journals
ISSN - 1178-6957
DOI - 10.2147/sccaa.s248526
Subject(s) - sox2 , mesenchymal stem cell , basic fibroblast growth factor , biology , stem cell , transdifferentiation , neurotrophic factors , microbiology and biotechnology , cancer research , immunology , growth factor , medicine , transcription factor , genetics , receptor , gene
Hearing Loss (HL) is known as the most common sensory processing disorder across the world. An effective treatment which has been currently used for patients suffering from this condition is cochlear implant (CI). The major limitation of this treatment is the need for a healthy auditory neuron (AN). Accordingly, mesenchymal cells (MCs) are regarded as good candidates for cell-based therapeutic approaches. The present study aimed to investigate the potentials of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) for differentiation towards ANs along with using treatments with growth factors and microRNA (miRNA) transfection in vitro .