Open AccessThe Effect of Intratesticular Injection of Human Adipose-Derived Mesenchymal Cell on Testicular Oxidative Stress and Spermatogenesis Process in the Varicocele Rat Model
Author(s) -
Safendra Siregar,
Bambang Sasongko Noegroho,
Ricky Adriansjah,
Akhmad Mustafa,
Ananta Bonar
Publication year - 2021
Publication title -
research and reports in urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 20
ISSN - 2253-2447
DOI - 10.2147/rru.s330634
Subject(s) - varicocele , spermatogenesis , medicine , malondialdehyde , andrology , oxidative stress , male infertility , infertility , reproductive technology , adipose tissue , endocrinology , urology , biology , embryo , cryopreservation , genetics , microbiology and biotechnology , pregnancy
Varicocele is the predominant cause of male infertility. Reactive oxygen species was found in varicocele which induce the lipid peroxidation process in the plasma membrane of spermatozoa and may cause damage to spermatozoa in semen and seminiferous tubules, disrupting spermatogenesis. Human adipose derived stem cells (hADSC) can suppress oxidative stress in some oxidative injury model. This study investigate the effect of intratesticular hADSC injection on malondialdehyde (MDA) level and spermatogenesis process by histopathological examination in the varicocele rat model.