Open AccessProfiling of Androgen-Dependent Enhancer RNAs Expression in Human Prostate Tumors: Search for Malignancy Transition Markers
Author(s) -
Koichi Nishimura,
Jinichi Mori,
Takahiro Sawada,
Shuhei Nomura,
Alexander Kouzmenko,
Katsuhisa Yamashita,
Yoshitsugu Kanemoto,
Tomohiro Kurokawa,
Akira Hayakawa,
Suguru Tokiwa,
Michihisa Ochi,
Hiroaki Shimmura,
Shigeaki Kato
Publication year - 2021
Publication title -
research and reports in urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 20
ISSN - 2253-2447
DOI - 10.2147/rru.s328661
Subject(s) - prostate cancer , lncap , cancer research , enhancer , carcinogenesis , androgen receptor , biology , prostate , medicine , cancer , transcription factor , gene , genetics
Although the ability of androgens to promote prostate cancer development has been known for decades, the molecular mechanisms of androgen receptor (AR) signaling in the tumorigenesis remain unclear. Enhancer RNAs (eRNAs) transcribed from strong enhancers, or super-enhancers (SEs), have recently emerged as a novel class of regulatory non-coding RNAs (ncRNAs) that facilitate transcription, including that of androgen target genes, through chromatin looping to position enhancers proximate to the promoters. The aim of this study was to assess androgen-dependent transcription in prostate tumors of eRNAs (designated as KLK3eRNAs) from the SE of the KLK3 gene encoding the prostate-specific antigen (PSA) protein, a clinical marker of prostate carcinogenesis.