Open AccessExpression of Phosphodiesterase (PDE) Isoenzymes in the Human Male and Female Urethra
Author(s) -
Harrina Erlianti Rahardjo,
Stefan Ückert,
A. Bannowsky,
Markus A. Kuczyk,
George T. Kedia
Publication year - 2021
Publication title -
research and reports in urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 20
ISSN - 2253-2447
DOI - 10.2147/rru.s291962
Subject(s) - isozyme , urethra , phosphodiesterase , messenger rna , pde10a , western blot , urination , medicine , endocrinology , biology , urinary system , enzyme , gene , anatomy , genetics , biochemistry
Although it has been supposed that the NO/cyclic GMP system produces inhibitory signals to reduce the resistance of the bladder outlet and urethra during the micturition phase, little is known on the mechanisms controlling the function of urethral smooth muscle. The aim of the present study was to examine in the male and female urethra the expression of phosphodiesterase (PDE) isoenzymes, known as key proteins of the cyclic GMP/AMP signaling.