Open Access<p>Urinary Cytochrome C and Caspase-3 as Novel Biomarker of Renal Function Impairment in Unilateral Ureteropelvic Junction Obstruction Model of Wistar Rats</p>
Author(s) -
Jupiter Sibarani,
Tjahjodjati Tjahjodjati,
Nur Atik,
Dedi Rachmadi,
Akhmad Mustafa
Publication year - 2020
Publication title -
research and reports in urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 20
ISSN - 2253-2447
DOI - 10.2147/rru.s259237
Subject(s) - medicine , renal function , ureteropelvic junction , urinary system , biomarker , caspase 3 , cytochrome c , endocrinology , urology , apoptosis , biochemistry , hydronephrosis , biology , programmed cell death
Prolonged obstruction in UPJO would lead to kidney destruction. It is important to find a non-invasive biomarker for early detection of renal impairment before definitive treatment for UPJO. In this study, we aim to evaluate the role of urinary cytochrome c and caspase-3 as a novel biomarker to predict renal function impairment in a UPJO model in Wistar rats.