Open AccessGenetic Polymorphisms of Pesticide-Metabolizing Enzymes and Transporters in Agricultural Workers and Thyroid Hormone Levels
Author(s) -
Jintana Sirivarasai,
Suwannee Chanprasertyothin,
Pornpimol Kongtip,
Susan Woskie
Publication year - 2021
Publication title -
risk management and healthcare policy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.828
H-Index - 22
ISSN - 1179-1594
DOI - 10.2147/rmhp.s314510
Subject(s) - single nucleotide polymorphism , thyroid , hormone , genotyping , pesticide , endocrinology , medicine , biology , gene , genetics , genotype , agronomy
Chronic exposure to pesticides has been associated with thyroid dysfunction owing to their endocrine disruption ability. Genetic variations in genes encoding phase I and II enzymes and phase III transporters are partly responsible for individual responses to chemical pesticides. This study investigated the association between variations in genes involved in pesticide metabolism and altered thyroid hormone concentrations.