Open AccessEstimated Thresholds of Minimum Necessary Adherence for Effective Treatment with Direct Oral Anticoagulants – A Retrospective Cohort Study in Health Insurance Claims Data
Author(s) -
Lucas Wirbka,
Walter E. Haefeli,
Andreas D. Meid
Publication year - 2021
Publication title -
patient preference and adherence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 48
ISSN - 1177-889X
DOI - 10.2147/ppa.s324315
Subject(s) - medicine , dabigatran , rivaroxaban , apixaban , medical prescription , atrial fibrillation , stroke (engine) , confidence interval , retrospective cohort study , cohort , population , emergency medicine , warfarin , pharmacology , mechanical engineering , environmental health , engineering
An essential contribution regarding the prevention of thromboembolic events in patients with (non-valvular) atrial fibrillation (AF) is good adherence to direct oral anticoagulants (DOACs). However, it is an open question what "good" adherence means for DOACs or below which threshold non-adherence is clinically relevant for AF patients. Ultimately, such a classification could prevent strokes and associated costs through adjusted treatment regimens or supportive measures.