Open AccessEffect of Apolipoprotein E ε4 Allele on the Progression of Carotid Atherosclerosis Through Apolipoprotein Levels
Author(s) -
Wenbing Ma,
Liting Zhang,
Luo Li,
Suya Zhang,
Shuang Yang,
HengChen Yao,
Lei Zhang,
XiaoYun Lu,
Weiyi Feng
Publication year - 2022
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s367471
Subject(s) - apolipoprotein e , allele , genotype , medicine , endocrinology , apolipoprotein b , confounding , risk factor , allele frequency , cholesterol , genetics , disease , gene , biology
The apolipoprotein E (ApoE) genetic variation may be involved in the development of Carotid Atherosclerosis (CAS) disease. So far, few data are available on the role of ApoE isoforms in CAS. The association between this ApoE genotype and CAS remains controversial. The aim of this study was to investigate ApoE gene polymorphism in relation to CAS and the relationships between ApoE gene polymorphism and plasma lipid levels in the ShaanXi Han populations.