Open AccessGene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer
Author(s) -
Yue Li,
DaLei Zhou,
Qing Liu,
Weijie Zhu,
ZuLu Ye,
Caiyun He
Publication year - 2022
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s360912
Subject(s) - fto gene , single nucleotide polymorphism , medicine , haplotype , allele , obesity , gene , cancer , gastroenterology , endocrinology , genetics , oncology , genotype , biology
Fat mass and obesity-associated protein (FTO) and AlkB homolog 1 (ALKBH1) are m6A demethylases that have been demonstrated to be associated with the overall survival of patients with gastric cancer (GC). This study investigates the influence of genetic variants of FTO and ALKBH1 on susceptibility to GC.