Open AccessInducible Nitric Oxide Synthase iNOS-954-G>C and Ex16+14-C>T Gene Polymorphisms and Susceptibility to Vitiligo in the Saudi Population
Author(s) -
Fahad Al-Harthi,
Ghaleb Bin Huraib,
Md Mustafa,
Yasser Alqubaisy,
Naief Al-Nomair,
Nour Abdurrahman,
Abdulrahman Alasmari
Publication year - 2022
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s344415
Subject(s) - vitiligo , genotype , medicine , allele , pathogenesis , nitric oxide synthase , population , gastroenterology , endocrinology , genetics , immunology , nitric oxide , gene , biology , environmental health
Vitiligo is an acquired pigmentary skin disorder with regional disappearance of melanocytes. Multigenic inheritance has been proposed in the pathogenesis of vitiligo. The present study aimed to investigate the possible association of inducible nitric oxide synthase polymorphisms iNOS-954-G/C (rs1800482 G>C) and iNOS-Ex16+14-C/T (rs2297518 C>T) with vitiligo in the Saudi population, if any.