Open AccessGenetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese
Author(s) -
Youxin Wang,
Qingqing Huang,
Xinglei Huang,
Hongda Zhao,
Bin Guan,
Kechen Ban,
Xuefeng Zhu,
Zhixing Ma,
Yanmei Tang,
Zhaohui Su,
Qingqing g
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s335555
Subject(s) - medicine , gene , protein subunit , genetics , bioinformatics , biology
Protein phosphatase 2A (PP2A, a serine/threonine phosphatase) is frequently inactivated in many types of cancer, including primary liver cancer (PLC). Genetic variations in PP2A subunits have been reported to be associated with the risk of many types of cancer but rarely in PLC. This study aims to assess the association between functional polymorphisms of PP2A subunit genes and the risk of PLC in Chinese.