Open AccessSearch for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients
Author(s) -
Anastasiia S. Boiko,
Ivan V Pozhidaev,
Diana Z. Paderina,
А. В. Бочарова,
Irina A. Mednova,
Olga Yu Fedorenko,
E. Kornetova,
Anton J. M. Loonen,
A. Semke,
Н. А. Бохан,
Светлана Иванова
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s327353
Subject(s) - medicine , metabolic syndrome , obesity , abdominal obesity , body mass index , pharmacogenetics , genotyping , single nucleotide polymorphism , schizophrenia (object oriented programming) , antipsychotic , bioinformatics , snp , polymorphism (computer science) , allele , oncology , endocrinology , genotype , genetics , psychiatry , gene , biology
Metabolic syndrome (MetS) is characterized by abdominal obesity, hyperglycaemia, dyslipidaemia and hypertension. FTO gene has been implicated in the pathogenesis of obesity, but the available scientific data concerning their relationship to antipsychotic drug-induced obesity and metabolic syndrome is still incomplete and inconsistent, which indicates that continuing the investigation of this gene's role is necessary.