Open AccessThe Effects of Gene Variations of GABRA2, GABRB1, GABRG2, GAD1 and SLC1A3 on Patients with Propofol During Anesthesia Induction
Author(s) -
Lingyi Zhang,
Zhuoling Zheng,
Wudi Ma,
Shuyu Zhang,
Faling Xue,
Haini Wang,
Ye He,
Fang Ye,
Shouning Zhou,
Yongzi Wen,
Xiaoyan Li,
Wenqi Huang,
Min Huang,
Jiali Li,
Zhongxing Wang
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s326885
Subject(s) - medicine , propofol , anesthesia , pharmacology
Propofol is one of the most commonly used intravenous sedatives in general anesthesia, while the individual variations of propofol are apparent. The objective of this study was to investigate the influence of genetic variations in GABAergic neurons and glutamatergic neurons on time to loss of consciousness (LOC) and the incidence of hypotension during anesthesia induction.