Open AccessNUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy
Author(s) -
Aswin Anand Pai,
Ajith Mohan,
Esther Sathya Bama Benjamin,
Raveen Stephen Stallon Illangeswaran,
Infencia Xavier Raj,
Nancy Beryl Janet,
Arun Kumar Arunachalam,
M. Kavitha,
Uday Kulkarni,
Anup J. Devasia,
Fouzia Na,
Aby Abraham,
Alok Srivastava,
Biju George,
Vikram Mathews,
Anu Korula,
Poonkuzhali Balasubramanian
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s325813
Subject(s) - medicine , cohort , itpa , neutropenia , thiopurine methyltransferase , prospective cohort study , gastroenterology , chemotherapy , immunology , ribavirin , azathioprine , disease , hepatitis c virus , virus
Severe myelosuppression in patients with acute lymphoblastic leukemia (ALL) undergoing 6-MP-based maintenance therapy is attributed to TPMT gene polymorphisms, which is rare in Asian populations. This study aims to evaluate the role of selected polymorphisms in NUDT15, ITPA , and MRP4 genes in addition to TPMT in predicting 6-MP intolerance during ALL maintenance therapy.