Open AccessGenetic and Non-Genetic Factors Impact on INR Normalization in Preprocedural Warfarin Management
Author(s) -
Islam Eljilany,
Mohamed Elarref,
Nabil Shallik,
AbdelNaser Elzouki,
Loulia Bader,
Ahmed El-Bardissy,
Osama Abdelsamad,
Daoud AlBadriyeh,
Larisa H. Cavallari,
Hazem Elewa
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s322743
Subject(s) - medicine , warfarin , vkorc1 , cyp2c9 , genotyping , population , cohort , genotype , atrial fibrillation , genetics , gene , environmental health , cytochrome p450 , metabolism , biology
Annually, 10% of warfarin patients will likely need to stop warfarin prior to elective surgery to achieve a baseline international normalization ratio (INR) level (INR ≤ 1.2) at the time of the procedure. This study explores the influence of genetic and non-genetic factors on INR normalization in the Arab (major part of Near Eastern) population in preprocedural warfarin management.