Open AccessClinical Observation of Gene Polymorphism of Olanzapine or Aprepitant in Prevention of CINV
Author(s) -
Yilan Jin,
Gaowa Jin,
Jun Zhao,
Caihong Jiang,
Lanzhen Zhao,
Ying Jiang,
Feng Chen,
Hui Li,
Wenjuan Wang,
Yungaowa Wu,
Guang Liu,
Xiaorong Li,
Min Gu,
Xiaomei Li,
Quanfu Li
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s317229
Subject(s) - aprepitant , olanzapine , medicine , chemotherapy induced nausea and vomiting , gastroenterology , nausea , oncology , vomiting , pharmacology , anesthesia , antiemetic , psychiatry , schizophrenia (object oriented programming)
The present study aims to investigate the correlation between the gene polymorphisms of the multidrug resistance protein 1 (ABCB1), the intron region of transcriptional factor (GTF2E1) and catechol- O -methyltransferase (COMT), dopamine receptor (DRD2), and the control of chemotherapy-induced nausea and vomiting (CINV) by olanzapine or aprepitant in a Chinese population under a fractionated cisplatin dosing pattern.