Open AccessThe Phenomenon of Gene Rearrangement is Frequently Associated with TP53 Mutations and Poor Disease-Free Survival in Hepatocellular Carcinoma
Author(s) -
Fei He,
Kejuan Song,
Ge Guan,
Junyu Huo,
Xinquan Yang,
Tianxiang Li,
Chao Liu,
Qiangqiang Zhu,
Ning Fan,
Yuan Guo,
Liqun Wu
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s313848
Subject(s) - hccs , medicine , hepatocellular carcinoma , proportional hazards model , gastroenterology , carcinoma , retrospective cohort study , oncology , pathology
Gene rearrangements (GRs) have been reported to be related to adverse prognosis in some tumours, but the relationship in hepatocellular carcinoma (HCC) remains less studied. The objective of our study was to explore the clinicopathological characteristics and prognosis of HCC patients (HCCs) with GRs (GR-HCCs).