Open AccessA Functional Variant rs2072915 is Associated with the Susceptibility and Mortality of Cervical Squamous Cell Carcinoma
Author(s) -
Renliang Li,
Jiaohong Wu,
Min Guo,
Lixiao Sha,
Shuqi Xia,
Liang Xu
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s310504
Subject(s) - medicine , genotype , pathogenesis , genetic predisposition , locus (genetics) , basal cell , polymerase chain reaction , gastroenterology , oncology , gene , genetics , biology , disease
Genetic variant has been demonstrated to be a risk factor for the occurrence and outcome of cervical squamous cell carcinoma (CSCC). From previous genome wide association studies, 6p21.32 has been identified as a susceptibility locus of CSCC. The purpose of this study was to investigate the association of a polymorphism rs2072915 located in 6p21.32 with the risk of CSCC and examine the potential mechanism of the rs2072915 in CSCC pathogenesis.