Open AccessCYP2C9*3/*3 Gene Expression Affects the Total and Free Concentrations of Valproic Acid in Pediatric Patients with Epilepsy
Author(s) -
Xiaolian Wu,
Weichong Dong,
Haoran Li,
Xiaohong Yang,
Yiran Jin,
Zhiqing Zhang,
Ye Jiang
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s301893
Subject(s) - valproic acid , medicine , phenobarbital , cyp2c9 , therapeutic drug monitoring , pharmacology , epilepsy , phenytoin , therapeutic index , metabolism , pharmacokinetics , endocrinology , drug , cytochrome p450 , psychiatry
To perform therapeutic drug monitoring (TDM) of total and free plasma valproic acid (VPA) concentrations in pediatric patients with epilepsy and to analyze related factors.