Open Access<p>Single-Nucleotide Polymorphisms in Genes Predisposing to Leprosy in Leprosy Household Contacts in Zhejiang Province, China</p>
Author(s) -
Yun-Liang Shen,
Siyu Long,
Wenming Kong,
Limei Wu,
Li-Juan Fei,
Qiang Yao,
Hongsheng Wang
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s286270
Subject(s) - leprosy , single nucleotide polymorphism , medicine , logistic regression , odds ratio , allele , multifactor dimensionality reduction , genotype , genome wide association study , genetic model , demography , genetics , gene , immunology , biology , sociology
Genome-wide association studies (GWAS) have identified multiple genetic variants associated with leprosy. To investigate the single and combined associations between single-nucleotide polymorphisms (SNPs) and the development of leprosy, we therefore performed generalized multi-analytical (GMDR) analysis in Chinese leprosy household contacts and constructed a risk prediction model.