Open AccessMitochondrial DNA in Fresh versus Frozen Embryo Culture Media of Polycystic Ovarian Syndrome Patients Undergoing Invitro Fertilization: A Possible Predictive Marker of a Successful Pregnancy
Author(s) -
Ghadir A. Sayed,
H. A. Al-Sawaf,
Ahmed H. Al-Sawaf,
Mohamed Saeid,
Ahmed M. Maged,
I. K. A. Ibrahim
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s284064
Subject(s) - polycystic ovary , embryo , andrology , medicine , in vitro fertilisation , gynecology , embryo transfer , embryo culture , pregnancy , biology , cryopreservation , genetics , obesity , insulin resistance
Frozen embryos transfer (ET) may improve the live-birth and reduce rates of ovarian hyperstimulation in polycystic ovary syndrome (PCOS) patients. Morphological criteria are the classical way for embryo selection, yet recently, many biochemical and genetic markers have been developed. This study aimed to compare fresh and frozen ET using the mtDNA/gDNA ratio of embryo secretome and the possibility of using this ratio as a predictive marker of PCOS pregnancy rate.