Open AccessGenetic Variants of the MIF Gene and Susceptibility of Rectal Cancer
Author(s) -
Dongyu Chuo,
Dongxin Lin,
Mingdi Yin,
Yuze Chen
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s282653
Subject(s) - macrophage migration inhibitory factor , medicine , carcinogenesis , colorectal cancer , genetic predisposition , biomarker , gene , inflammation , cancer , immunology , in vivo , cytokine , cancer research , oncology , biology , genetics , disease
Rectal cancer (RC) has been documented to be a highly invasive malignant neoplasm worldwide. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in cell-mediated immunity, immunoregulation, inflammation. In vitro and in vivo studies have identified that MIF was involved in the carcinogenesis and progression of RC.