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In Eritrea, artesunate-amodiaquine is the first-line treatment against uncomplicated malaria. Amodiaquine, which is mainly bio-transformed by CYP2C8, is known to be associated with adverse events of different severity. Extrapyramidal events are among the less common but have been reported with non-negligible frequency in Eritrea. This study was conducted to investigate the allele frequencies of CYP2C8*2 and *3 , both associated with decreased amodiaquine metabolism, among the Eritrean population.

pharmacogenomics and personalized medicine

&lt;p&gt;Prevalence of &lt;em&gt;CYP2C8*2&lt;/em&gt; and &lt;em&gt;*3&lt;/em&gt; among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment&lt;/p&gt;