Open AccessInfluence of PSRC1, CELSR2, and SORT1 Gene Polymorphisms on the Variability of Warfarin Dosage and Susceptibility to Cardiovascular Disease
Author(s) -
Laith N. AL-Eitan,
Barakat Z Elsaqa,
Ayah Y. Almasri,
Hatem A Aman,
Rame Khasawneh,
Mansour A. Alghamdi
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s274246
Subject(s) - warfarin , medicine , vkorc1 , pharmacogenomics , pharmacogenetics , dosing , single nucleotide polymorphism , genome wide association study , disease , cyp2c9 , pharmacology , genotype , atrial fibrillation , genetics , gene , biology , cytochrome p450 , metabolism
Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. Several cardiovascular diseases require therapy with warfarin, an anticoagulant with large interindividual variability resulting in dosing difficulties. The selected genes and their polymorphisms have been implicated in several Genome-Wide Association Study (GWAS) to be associated with cardiovascular disease.