Open Access<p>Sex-Specific Influence of the SCARB1 Rs5888 SNP on the Serum Lipid Response to Atorvastatin in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention</p>
Author(s) -
DongFeng Wu,
Dan Lin,
Feng Hwa Lu,
Qin-Chen Liao,
Yu-juan Wu,
Zhou Wang,
Kun Yu,
Weijun Li,
Jin-Long Deng
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s273346
Subject(s) - medicine , atorvastatin , percutaneous coronary intervention , acute coronary syndrome , cardiology , myocardial infarction
Epidemiological studies have shown that there are sex differences in blood lipid levels and lipid responses to statins. Previous studies have shown that the rs5888 single nucleotide polymorphism (SNP) in the scavenger receptor class B type 1 ( SCARB1 ) gene is associated with serum lipid levels in a sex-specific manner. The present study was undertaken to detect the sex-specific influence of the SCARB1 rs5888 SNP on the serum lipid response to atorvastatin in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).