Open AccessCYP2C9 Variations and Their Pharmacogenetic Implications Among Diverse South Asian Populations
Author(s) -
Sheikh Nizamuddin,
Shivendra Dubey,
Sakshi Singh,
Saurav Sharma,
Pratheusa Machha,
Kumarasamy Thangaraj
Publication year - 2021
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s272015
Subject(s) - cyp2c9 , pharmacogenetics , genetics , haplotype , allele , medicine , genotype , 1000 genomes project , allele frequency , pharmacogenomics , biology , gene , evolutionary biology , single nucleotide polymorphism
Allelic frequency distribution of drug metabolizing enzyme genes among populations is important to identify risk groups for adverse drug reaction and to select representative populations for clinical trials. Although India emerged as an important hub for clinical trials, information about the pharmacogenetic diversity for this region is still lacking. Here, we investigated genetic diversity of cytochrome-P450-2C9 ( CYP2C9 ) gene which metabolizes wide range of drugs and is highly expressed in the human liver.