Open Access<p>Functional Genetic Variation in the 3′-UTRNTRK2 is Associated with Risk of Ischemic Stroke</p>
Author(s) -
Jiajia Shi,
Ying Sun,
Jiajia Hua
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s270319
Subject(s) - medicine , genotyping , genotype , neurotrophic factors , oncology , brain derived neurotrophic factor , single nucleotide polymorphism , bioinformatics , gene , genetics , receptor , biology
Stroke is a leading cause of death and disability worldwide. It remains difficult to treat brain injury and improve functional rehabilitation after cerebral ischemia. Brain-derived neurotrophic factor ( BDNF ) is involved in ischemic stroke (IS) through interactions in the CREB1-BDNF-NTRk2 pathway. In this study, we aimed to determine the association of NTRK2 gene polymorphisms and the effects of intergenetic interactions in the Chinese population.