Open AccessSLCO1B1 and ABCG2 Gene Polymorphisms in a Thai Population
Author(s) -
Punyabhorn Rattanacheeworn,
Montri Chamnanphon,
Siriwan Thongthip,
Wonngarm Kittanamongkolchai,
Natavudh Townamchai,
Yingyos Avihingsa,
Udomsak Udomnilobol,
Thomayant Prueksaritat,
Suree Jianmongkol,
Pajaree Chariyavilaskul
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s268457
Subject(s) - slco1b1 , abcg2 , genotype , haplotype , pharmacogenetics , genotyping , allele frequency , allele , medicine , genetics , single nucleotide polymorphism , atp binding cassette transporter , pharmacology , biology , gene , transporter
Genetic polymorphisms of drug transporters influence drug transporter activity and alter pharmacokinetic profiles of the drugs. Organic anion transporting polypeptide 1B1 (OATP1B1) and breast cancer resistance protein (BCRP) are important transporters encoded by solute carrier organic anion transporter family member 1B1 ( SLCO1B1 ) gene and ATP-binding cassette subfamily G member 2 ( ABCG2 ) gene, respectively. Polymorphisms in these genes are associated with increased plasma statins concentrations, statin-induced myopathy and poor response to allopurinol treatment.