Open Access<p>IL-6 −572C>G and CARD8 304T>A Genetic Polymorphisms are Associated with the Absolute Neutrophil Count in Patients with Hematological Malignancies Under Chemotherapy: An Application of Multilevel Models to a Preliminary Pharmacogenetic Study</p>
Author(s) -
Matías F. Martínez,
Enzo Alveal,
Tomas G. Soto,
Eva Bustamante,
Fernanda Ávila,
Shrikant I. Bangdiwala,
Ivonne Flores,
Claudia Benavides,
Ricardo Morales,
Nelson Varela,
Luis A. Quiñones
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s261208
Subject(s) - medicine , gastroenterology , chemotherapy , absolute neutrophil count , genotype , neutropenia , oncology , acute leukemia , leukemia , gene , biochemistry , chemistry
Neutropenia is a common event in patients undergoing cytotoxic chemotherapy for the treatment of a hematological malignancy. Some polymorphisms, as IL-6 -572C>G (rs1800796), IL-1β -31 G>A (rs1143627), and CARD8 304T>A (rs2043211), in genes related to the inflammatory process, could affect the level of absolute neutrophil count (ANC) after chemotherapy. Since an efficient inflammatory process enhances neutrophil survival, we hypothesize that these polymorphisms are associated with ANC.