Open Access<p>Negative Association Between lncRNA <em>HOTTIP</em> rs3807598 C>G and Hirschsprung Disease</p>
Author(s) -
Yi Zheng,
Zhuo Zhang,
Xiaoli Xie,
Li-Feng Lu,
Qiuming He,
Wei Zhong
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s249649
Subject(s) - medicine , single nucleotide polymorphism , odds ratio , snp , genotype , confidence interval , gastroenterology , genetics , gene , biology
Hirschsprung disease (HSCR) is a congenital disease that arises from defective intestinal neural system. LncRNA HOTTIP is a critical gene in various diseases, including HSCR. No epidemiological studies have explored the correlation between lncRNA HOTTIP single nucleotide polymorphisms (SNPs) and HSCR risk. We here lead as a pioneer to explore whether SNPs in lncRNA HOTTIP impact the risk of HSCR and HSCR subtypes in an unrelated Chinese population.