Open Access<p>Genetic Polymorphisms in Transforming Growth Factor-β, Interferon-γ and Interleukin-6 Genes and Susceptibility to Behcet’s Disease in Saudi Population</p>
Author(s) -
Fahdah Al Okaily,
Seham Al-Rashidi,
Muhammad Mustafa,
Faris Bander Alrashdan
Publication year - 2020
Publication title -
pharmacogenomics and personalized medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 28
ISSN - 1178-7066
DOI - 10.2147/pgpm.s249361
Subject(s) - genotype , behcet's disease , medicine , allele , immunology , polymorphism (computer science) , population , immune system , restriction fragment length polymorphism , disease , genetics , gene , biology , environmental health
Behcet's disease (BD) is a complex, inflammatory, immune-mediated multi-systemic disease of unknown etiology. Cytokines play major roles in the pathophysiology of BD, and its production may be affected by polymorphism in cytokine genes. Hence, the present study was planned to investigate any possible association between the polymorphism in TGF-β, IFN-γ, and IL-6 genes and BD in the Saudi population.