Open AccessALK-Positive Anaplastic Large-Cell Lymphoma in a Patient with Chronic Lymphocytic Leukemia: A Case Report and Literature Review
Author(s) -
Qinchuan Yu,
Zhiqiang Zhao,
He Wang,
Lieyang Wang
Publication year - 2022
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s383779
Subject(s) - chronic lymphocytic leukemia , medicine , lymphoma , anaplastic lymphoma kinase , anaplastic large cell lymphoma , transformation (genetics) , malignant transformation , leukemia , aggressive lymphoma , cancer research , pathology , oncology , biology , gene , rituximab , biochemistry , malignant pleural effusion , lung cancer
Chronic lymphocytic leukemia (CLL) can experience histological transformation to a more aggressive lymphoma called "Richter's transformation". This transformation usually leads to diffuse large B cell lymphoma, though cases of T cell lymphoma have been identified. Here we report an extremely rare case of ALK (anaplastic lymphoma kinase) positive anaplastic large cell lymphoma. We performed detailed examination for this patient and reviewed related literatures to understand the transformation. Despite our best effort, this patient passed away shortly. Literature review shows no consensus on treatment and poor prognosis of this condition. We intend to report this case and explore novel treatment possibilities for these patients.