Open AccessUpregulation of Cartilage Oligomeric Matrix Protein Predicts Poor Prognosis in Urothelial Carcinoma
Author(s) -
YuHsuan Kuo,
Hong-Yue Lai,
TiChun Chan,
Chung-Hsi Hsing,
Steven Kuan-Hua Huang,
Kun-Lin Hsieh,
TzuJu Chen,
WanShan Li,
Jhih-Cheng Lu,
ChienFeng Li
Publication year - 2022
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s370028
Subject(s) - medicine , cartilage oligomeric matrix protein , hazard ratio , perineural invasion , proportional hazards model , cancer , bladder cancer , metastasis , carcinoma , urothelium , oncology , urology , pathology , urinary system , osteoarthritis , confidence interval , alternative medicine
Cartilage oligomeric matrix protein (COMP) is known as a large pentameric glycoprotein, which interacts with various extracellular matrix proteins in tissues. COMP has been reported to play a role in multiple connective tissue disorders. Recently, elevated COMP levels have been found to be associated with increased tumor size, metastases, faster recurrence of cancer, and overall poorer survival in several cancers. However, the clinical importance of COMP in urothelial carcinoma remains unclear. We investigated the association between COMP expression and clinical outcomes in urothelial carcinoma.