Open AccessGenetic and Clinicopathologic Characteristics of Papillary Thyroid Carcinoma in the Chinese Population: High BRAF Mutation Allele Frequency, Multiple Driver Gene Mutations, and RET Fusion May Indicate More Advanced TN Stage
Author(s) -
Zhihong Wang,
Peng Tang,
Surong Hua,
Jinyang Gao,
Bin Zhang,
Hua Wan,
Qixi Wu,
Jiaxin Zhang,
Ge Chen
Publication year - 2022
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s339114
Subject(s) - medicine , thyroid carcinoma , exact test , population , oncology , stage (stratigraphy) , confidence interval , gastroenterology , thyroid cancer , allele , mutation , odds ratio , thyroid , genetics , gene , biology , paleontology , environmental health
To describe the genetic landscape and clinical characteristics of Chinese patients diagnosed with papillary thyroid cancer (PTC) and to determine which high-risk genetic characteristics suggest a likelihood of lymph node metastasis (LNM) and lateral lymph node metastasis (LLNM).