Open AccessM2-Type Macrophages Induce Tregs Generation by Activating the TGF-β/Smad Signalling Pathway to Promote Colorectal Cancer Development
Author(s) -
Xin Ma,
Yu Gao,
Yanlei Chen,
Jinhao Liu,
Chunyu Yang,
Bao Cui-fen,
Yanping Wang,
Yang Feng,
Xiaoyu Song,
Shifeng Qiao
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s336548
Subject(s) - cd163 , foxp3 , smad , colorectal cancer , medicine , cancer research , immunohistochemistry , downregulation and upregulation , transforming growth factor , cancer , immune system , pathology , oncology , immunology , macrophage , biology , gene , biochemistry , in vitro
The increase of both M2-type macrophages and Tregs is closely associated with the development of colorectal cancer. However, the mechanism of their interaction is still unclear. In this study, we investigated the correlation of M2-type macrophages with Tregs and the possible mechanisms between them.