Open AccessEndometrial Tumors with MSI-H and dMMR Share a Similar Tumor Immune Microenvironment
Author(s) -
Yiran Song,
Ye Gu,
Xiang Hu,
Mengfei Wang,
Qizhi He,
Yiran Li
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s324641
Subject(s) - microsatellite instability , tumor infiltrating lymphocytes , dna mismatch repair , endometrial cancer , immunohistochemistry , cancer research , pd l1 , tumor microenvironment , immune system , immune checkpoint , cd8 , cancer , cytotoxic t cell , biology , immunotherapy , medicine , oncology , immunology , colorectal cancer , genetics , gene , microsatellite , in vitro , allele
Microsatellite instability (MSI) and mismatch repair deficiency (dMMR) are important biomarkers for predicting responses to immune checkpoint inhibitor (ICI) therapies. Although PCR-based tests for high MSI (MSI-H) and dMMR yield highly concordant results in endometrial cancer (EC), it is unclear whether this is true for MSI-H and MMR detected by next-generation sequencing (NGS) and immunohistochemistry (IHC), respectively. This study investigated whether EC with MSI-H identified by NGS and dMMR identified by IHC have similar tumor immune microenvironments.