Open AccessTetrandrine Inhibits Epithelial-Mesenchymal Transition in IL-6-Induced HCT116 Human Colorectal Cancer Cells
Author(s) -
ShihChang Tsai,
Wei-Chei Wu,
Jai Sing Yang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s324552
Subject(s) - tetrandrine , mtt assay , viability assay , gentamicin protection assay , epithelial–mesenchymal transition , cell migration , colorectal cancer , cell culture , cancer research , cell , metastasis , microbiology and biotechnology , cancer cell , chemistry , biology , cancer , pharmacology , biochemistry , genetics
Patients with colorectal cancer (CRC) often develop distant metastases, which significantly reduces the 5-year survival rate. Epithelial-mesenchymal transition (EMT) is a crucial process for the invasion and metastasis of cancer cells. Tetrandrine has been reported to inhibit the viability and EMT of CRC cells; however, to the best of our knowledge, the molecular mechanism remains undetermined.