Open AccessTFF-1 Functions to Suppress Multiple Phenotypes Associated with Lung Cancer Progression
Author(s) -
Kentaro Minegishi,
Yoh Dobashi,
Hiroyoshi Tsubochi,
Koichi Hagiwara,
Yuko Ishibashi,
Sachiyo Nomura,
Ritsuko Nakamura,
Yasukazu Ohmoto,
Shunsuke Endo
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s322697
Subject(s) - transfection , cell cycle , cell growth , flow cytometry , microbiology and biotechnology , cell culture , viability assay , apoptosis , biology , matrigel , cell , cell migration , chemistry , cancer research , biochemistry , genetics
Trefoil Factor (TFF) is a member of a protein family comprised of three isoforms, of which TFF-1 exhibits antithetical functions; promotion or suppression of cell proliferation, survival and invasion, depending on the cancer type. However, the pathobiological function of TFF-1 in lung carcinoma has been still unclear.