Open AccessClinical Application of Tumor Vascular Disrupting Therapy: A Systematic Review and Meta-Analysis
Author(s) -
Wen Tsang,
Lu Gan,
Zhikun Zhang,
Tong Li,
Yiqun Luo,
Liping Zhong,
Yong Huang
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s321658
Subject(s) - medicine , meta analysis , randomized controlled trial , oncology , cochrane library , clinical trial , systematic review , prostate cancer , radiation therapy , cancer , medline , political science , law
The occurrence, progression, invasion and metastasis of tumors depend on a tumor vascular network. Vascular disrupting agents (VDAs) are a new class of drugs targeting the tumor vasculature, by blocking the existing tumor blood vessels. However, there is no clear consensus on the clinical efficacy of tumor vascular disrupting therapy. In this study, we performed the first systematic review and meta-analysis of published clinical trials focused on tumor vascular disrupting therapies.